Literature summary for 2.3.1.B41 extracted from

Sosnowska, B.; Mazidi, M.; Penson, P.; Gluba-Brzozka, A.; Rysz, J.; Banach, M.
The sirtuin family members SIRT1, SIRT3 and SIRT6 their role in vascular biology and atherogenesis (2017), Atherosclerosis, 265, 275-282 .

Search for more literature for 2.3.1.B41

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	the C-terminus of SIRT6 is required for nuclear localization of the enzyme	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N6T7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipose tissue	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
NAD+-dependent histone deacetylase	-	Homo sapiens
NAD-dependent protein deacetylase	-	Homo sapiens
nicotinamide adenine dinucleotide-dependent histone deacetylase	-	Homo sapiens
SIRT6	-	Homo sapiens
sirtuin-6	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

General Information

General Information	Comment	Organism
evolution	sirtuins, silent mating-type information regulation 2 (SIRTs), are a family of nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases with important roles in regulating energy metabolism and senescence. SIRT6 reduces the upregulation of genes involved in inflammation, vascular remodeling, oxidative stress, and angiogenesis, including interleukin 1-beta	Homo sapiens
metabolism	role of SIRTs in human atherosclerosis, overview	Homo sapiens
additional information	the core domain of SIRT6 is flanked by an N-terminal, which is necessary for histone deacetylation and chromatin association, and a C-terminal, which is required for the nuclear localization of this SIRT subtype	Homo sapiens
physiological function	roles of SIRT6 and SIRT activators on the progression of atherosclerosis and ultimately on cardiac outcomes, such as myocardial infarction and mortality. Potential interactions of SIRTS with pathophysiological processes in atherosclerosis, overview	Homo sapiens

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Release 2023.1 (January 2023)